Babal Kant Jha Selected Research

2-5A-dependent ribonuclease (RNase L)

2/2014	Cell-type-specific effects of RNase L on viral induction of beta interferon.
1/2014	Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity.
9/2013	Role of ribonuclease L in viral pathogen-associated molecular pattern/influenza virus and cigarette smoke-induced inflammation and remodeling.
1/2012	Structural architecture of an RNA that competitively inhibits RNase L.
1/2011	New insights into the role of RNase L in innate immunity.
6/2007	Small-molecule activators of RNase L with broad-spectrum antiviral activity.
6/2007	A phylogenetically conserved RNA structure in the poliovirus open reading frame inhibits the antiviral endoribonuclease RNase L.
1/2006	Selection and cloning of poly(rC)-binding protein 2 and Raf kinase inhibitor protein RNA activators of 2',5'-oligoadenylate synthetase from prostate cancer cells.

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Babal Kant Jha Research Topics

Disease

6	Virus Diseases (Viral Diseases) 02/2014 - 06/2007
4	Infections 02/2014 - 06/2007
2	Demyelinating Diseases (Demyelinating Disease) 01/2013 - 01/2011
2	Neoplasms (Cancer) 07/2011 - 01/2011
1	Renal Cell Carcinoma (Grawitz Tumor) 01/2021
1	Kidney Neoplasms (Kidney Cancer) 01/2021
1	Inflammation (Inflammations) 09/2013
1	Chronic Obstructive Pulmonary Disease (COPD) 09/2013
1	Persistent Infection 01/2013
1	Leukemia 01/2011
1	familial Prostate cancer 01/2011
1	Bacterial Infections (Bacterial Infection) 01/2011
1	Prostatic Neoplasms (Prostate Cancer) 01/2006

Drug/Important Bio-Agent (IBA)

8	2-5A-dependent ribonuclease (RNase L)IBA 02/2014 - 01/2006
5	RNA (Ribonucleic Acid)IBA 02/2014 - 01/2006
3	CytokinesIBA 02/2014 - 01/2011
3	Antiviral Agents (Antivirals)IBA 02/2014 - 06/2007
2	EndonucleasesIBA 01/2012 - 06/2007
2	Adenosine Triphosphate (ATP)IBA 07/2011 - 06/2007
2	Ligases (Synthetase)IBA 01/2011 - 06/2007
2	InterferonsIBA 01/2011 - 12/2007
1	Naphazoline (All Clear)FDA LinkGeneric 01/2021
1	Transcription Factors (Transcription Factor)IBA 01/2021
1	Interferon Type IIBA 02/2014
1	Poly I-CIBA 02/2014
1	EndoribonucleasesIBA 01/2014
1	Pathogen-Associated Molecular Pattern MoleculesIBA 09/2013
1	Ribonucleases (Ribonuclease)IBA 09/2013
1	SmokeIBA 09/2013
1	Proteins (Proteins, Gene)FDA Link 01/2013
1	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 07/2011
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 07/2011
1	Sunitinib (Sutent)FDA Link 07/2011
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2011
1	Peptide Hydrolases (Proteases)FDA Link 06/2007
1	Carrier Proteins (Binding Protein)IBA 01/2006
1	2',5'-Oligoadenylate Synthetase (2',5' Oligoadenylate Synthetase)IBA 01/2006
1	Phosphatidylethanolamine Binding ProteinIBA 01/2006

Therapy/Procedure

1	Therapeutics 12/2007